Mediana Nis, Serbia: Flavius Valerius Constantinus, Constantine the Great (272 – 337, Roman Emperor 306 - 337) was born and raised in Naissus, in present-day Niš, Serbia. Mediana is one of his residences located at Naissus (Niš), Among other historical fact hi is known by issued the Edict of Milan in 313. Archaeological excavations parts.